Sativex

Definition: Sativex is the brand name for nabiximols, a prescription cannabis-based mouth spray containing roughly equal amounts of THC and CBD. It’s approved in the United Kingdom and many other countries to treat muscle stiffness and spasms (spasticity) caused by multiple sclerosis when other treatments haven’t helped. It isn’t approved by the FDA in the United States.

What Is in Sativex?

Sativex is made from extracts of cannabis plants, not synthetic compounds. Each spray delivers about 2.7 mg of THC and 2.5 mg of CBD. It’s sprayed under the tongue or inside the cheek, where it’s absorbed through the lining of the mouth.

How Does Sativex Work?

THC and CBD act on the body’s cannabinoid receptors and related targets involved in muscle tone and pain signaling. Patients typically start with one spray and increase gradually to find their dose. Many regulators require a trial period, and treatment is stopped if it doesn’t help.

Who Makes Sativex?

It was developed by GW Pharmaceuticals, the same company behind the CBD drug Epidiolex. GW was acquired by Jazz Pharmaceuticals in 2021.

What Are the Side Effects?

Common side effects include dizziness, fatigue, dry mouth, and mouth irritation where it’s sprayed. Because it contains THC, it can cause intoxicating effects and impair driving. It’s not recommended for people with a history of psychosis.

Related terms: Epidiolex, MMJ, Cannabidiol (CBD), THC

Sources: FDA: Regulation of Cannabis and Cannabis-Derived Products; National Institute on Drug Abuse: Cannabis (Marijuana).

This entry is for general education and isn’t medical advice.